It is really up to your style. If you prefer to do "silly" RPG games for example and then try to force yourself to do "serious" one. It is rather likely that end result would be way more worse than if you do what you like. It is not more about the style of your game but more about which style you can handle best, aka your own style. It is up to writer itself how he/she wants to balance his/her project's seriousness against silliness.
From the first glance, Death Note would be considered as a serious Anime, but when one actually watches and understands it, there is a lot comic relief in between of more serious scenes.
Then there is Gintama. Aside of some serious arcs, it does not take itself as a serious anime at all. Yet it can have suddenly entire episode made like it does not fit to entire anime with mainly comedy concept.
This post has been edited by Clord: Oct 5 2012, 11:50 PM